| Head of State | President | Salva Kiir Mayardit |
| First Vice President | Riek Machar |
| Second Vice President | James Wani Igga |
| Third Vice President | Taban Deng Gai |
| Fourth Vice President | Rebecca Nyandeng de Mabior |
| Fifth Vice President | Hussein Abdelbagi Akol |
| Head of Government | n/a | n/a |
| Finance | Minister of Finance and Planning | Agak Achuil Lual |
| Foreign | Minister of Foreign Affairs and International Cooperation | Mayiik Ayii Deng |
| Defense | Minister of Defense and Veterans’ Affairs | Angelina Teny |
| Health | Minister of Health | Elisabeth Acuei Yol |
| Justice | Minister of Justice and Constitutional Affairs | Reuben Madol Arol |
| Agriculture | Minister of Agriculture and Food Security | Josephine Joseph Lagu |
| Minister of Livestock and Fisheries | Onyoti Adigo Nyikwac |
| Energy | Minister of Petroleum | Puot Kang Chuol |
| Natural Resources | Minister of Mining | Martin Gama Abucha |
| Minister of Energy and Dams | Peter Marcello Nasir |
| Minister of Water Resources and Irrigation | Manawa Peter Gatkuoth |
| Education | Minister of Higher Education, Science and Technology | Gabriel Changson |
| Minister of General Education and Instruction | Awut Deng Achuil |
| Economy | Minister of Trade and Industry | Kuol Athian Mawien |
| Minister of Investment | Dhieu Mathok Diing |
| Digital/IT | n/a | n/a |
| Interior | Minister of Interior | Mahmoud Solomon Agook |
| Minister of National Security | Obuto Mamur Mete |
| Media | Minister of Information, Communication Technology, and Postal Services | Michael Makuei Lueth |
| Environment | Minister of Environment and Forestry | Josephine Napon Cosmos |
| Labor | Minister of Labor | James Hoth Mai |
| Others | Minister of Cabinet Affairs | Martin Elia Lomuro |
| Minister of Peace Building | Stephen Par Kuol |
| Minister of Parliamentary Affairs | Mary Nawai Martin |
| Minister of Presidential Affairs | Bamaba Marial Benjamin |
| Minister of Federal Affairs | Lasuba L. Wango |
| Minister of East African Community Affairs | Deng Alor Kuol |
| Minister of Land, Housing and Urban Development | Michael Chiangjiek |
| Minister of Wildlife, Conservation and Tourism | Rizik Zachariah Hassan |
| Minister of Public Service and Human Resource Development | Bangasi Joseph Bakosoro |
| Minister of Transport | Madut Biar Yel |
| Minister of Roads and Bridges | Simon Mijok Mijak |
| Minister of Gender and Social Welfare | Ayaa Benjamin Warille |
| Minister of Humanitarian Affairs | Peter Mayen Majongdit |
| Minister of Culture, Museums and National Heritage | Nadia Arop Dudi |
| Minister of Youth and Sports | Albino Bol Dhieu |
