| Head of State | President | Nana Addo Dankwa Akufo-Addo |
| Vice-President | Mahamudu Bawumia |
| Head of Government | n/a | n/a |
| Finance | Minister of Finance | Ken Ofori-Atta |
| Foreign | Minister of Foreign Affairs | Shirley Ayorkor Botchwey |
| Defense | Defense Minister | Dominic Nitiwul |
| Health | Minister of Health | Kwaku Agyeman Manu |
| Justice | Attorney General | Godfred Yeboah Dame |
| Agriculture | Minister of Agriculture | Owusu Afriyie Akoto |
| Minister of Fisheries and Aquaculture | Mavis Hawa Koomson |
| Energy | Minister of Energy | Matthew Opoku Prempeh |
| Natural Resources | Minister of Land and Natural Resources | Samuel A. Jinapor |
| Education | Minister of Education | Yaw Osei Adutwum |
| Economy | Minister of Trade and Industry | Alan Kyerematen |
| Digital/IT | n/a | n/a |
| Interior | Minister of the Interior | Ambrose Dery |
| Minister of National Security | Albert Kan Daapah |
| Media | Minister of Communication | Ursula Owusu-Ekuful |
| Environment | Minister of Environment, Science and Technology | Kwaku Afriyie |
| Labor | Minister of Employment and Labour Relations | Ignatius Baffour Awuah |
| Others | Minister of Monitoring and Evaluation | Anthony Akoto Osei |
| Minister of Local Government Decentralization and Rural Development | Dan Botwe |
| Minister of Gender, Children and Social Protection | Sarah Adwoa Safo |
| Minister of Transport | Kwaku Ofori Asiamah |
| Minister of Railways Development | John-Peter Amewu |
| Minister of Roads and Highways | Kwasi Amoako-Attah |
| Minister of Water and Sanitation | Cecilia Abena Dapaah |
| Minister of Works and Housing | Francis Asenso-Boakye |
| Minister of Tourism, Arts and Culture | Ibrahim Mohammed Awal |
| Minister of Information | Kojo Oppong Nkrumah |
| Minister of Youth and Sports | Mustafa Ussif |
| Minister of Chiefdoms and Religious Affairs | Ebenezer Kojo Kum |
| Minister of Parliamentary Affairs | Osei Kyei-Mensah-Bonsu |
