| Head of State | President | Ali Ben Bongo Ondimba |
| Head of Government | Prime Minister | Rose Christiane Ossouka Raponda |
| Finance | Minister of Economy and Recovery | Nicole Jeanine Lydie Roboty Mbou |
| Foreign | Minister of Foreign Affairs | Michael Moussa Adamo |
| Defense | Minister of National Defence | Félicité Ongouori Ngoubili |
| Health | Minister of Health | Guy Patrick Obiang Ndong |
| Justice | Minister of Justice, Keeper of the Seals and Human Rights Officer, in charge of human rights and gender equality | Erlyne Antonella Ndembet |
| Agriculture | Minister of Agriculture, Livestock, Fisheries and Food | Charles Mve Ella |
| Energy | Minister of State for Energy and Hydraulic Resources | Alain-Claude Bilie-By-Nze |
| Natural Resources | Minister of Oil, Gas and Mines | Vincent de Paul Massassa |
| Minister of Mining | Elvis Ossindji |
| Education | Minister of National Education, in charge of Civic Education | Camelia Ntoutoume-Leclercq |
| Minister of Higher Education, Scientific Research, Technology Transfer, Culture, and the Arts | Patrick Dauda Mouguima |
| Minister of Vocational Training | Raphaël Ngazouze |
| Economy | Minister of State for Industry | Pâcome Moubelet-Boubeye |
| Minister of Trade, Small and Medium Enterprises and Industry | Yves Fernand Mamfoumbi |
| Digital/IT | Minister of Digital Economy | Jean-Pierre Doukaga Kassa |
| Media | Minister of Communication and Digital Economy | Pascal Houangni Ambourouet |
| Interior | Minister of State for the Interior | Lambert Noël Matha |
| Minister of Housing and Urbanism | Olivier Nang Ekomie Komie |
| Environment | Minister of Water, Forests, the Sea and Environment, Responsible for Climate Plan and Land Use Plan | Lee White |
| Minister of Fisheries and Maritime Economy | Séverin Mayounou |
| Labor | Minister of Employment, Public service, Labor and Vocational Training, Government Spokesperson | Madeleine Edmée Berre |
| Others | Minister of State for the Relations with Constitutional Institutions and Independent Administrative Authorities | Denise Mekam'ne Edzidzie |
| Minister for the Promotion of Good Governance and the Fight Against Corruption | Francis Nkea Ndzigue |
| Minister of Decentralization, Cohesion and Territorial Development | Michel Menga M'Essone |
| Minister of Tourism | Jean-Norbert Diramba |
| Minister of Budget and Public Accounts | Edith Ekiri Mounombi |
| Minister of Transport | Brice Paillat |
| Minister of Sports, in charge of Associative Life | Franck Nguema |
| Minister of Public Works, Equipment and Infrastructure | Léon Armel Bounda Balonzi |
| Minister of Investment Promotion, Public-Private Partnerships, in charge of Improving the Business Environment | Hugues Mbadinga Madiya |
