| Head of State | President | Teodoro Obiang Nguema Mbasogo |
| Head of Government | Prime Minister | Francisco Pascual Obama Asue |
| Education | First Vice Prime Minister, Minister of Education, University Education and Sports | Clemente Engonga Nguema Onguene |
| Second Vice Prime Minister, in charge of Relations to the Parliament | Ángel Mesie Mibuy |
| Third Vice Prime Minister, in charge of human rights | Alfonso Nsue Mokuy |
| Finance | Minister for Finance, Economy and Planning | Valentin Ela Maye |
| Foreign | Minister for Foreign Affairs and Cooperation | Simeon Oyono Esono Angue |
| Defense | Minister for National Defence | Victoriano Bibang Nsue Okomo |
| Health | Minster for Health and Social Welfare | Diosdado Nsue Milang |
| Justice | Minister for Justice, Worship and Penitentiary Institutions | Salvador Ondo Ncumu |
| Agriculture | Minister for Agriculture, Livestock, Forests and the Environment | Francisca Eneme Efua |
| Minster for Fisheries and Water Resources | Adoración Salas Chonco |
| Energy | Minister for Industry and Energy | Miguel Ekua Ondo |
| Natural Resources | Minister for Mines and Hydrocarbons | Gabriel Mbega Obiang Lima |
| Economy | Minister for Trade and Promotion of Small and Medium-sized Businesses | Pastor Micha Ondo Bile |
| Digital/IT | Minister for Transport,Post and Telecommunications | Rufino Ovono Ondo |
| Interior | Minister of State for the Interior and Local Businesses | Faustino Ndong Esono Eyang |
| Media | Minister for Information, Press and Radio | Virgilio Seriche Riloha |
| Labor | Minister for Labor, Employment Promotion and Social Security | Alfredo Mitogo Mitogo Ada |
| Others | Minister of Civil Aviation | Norberto-Bartolome Mensuy Mañe Andeme |
| Minister for Public Works, Housing and Urban Planning | Clemente Ferreiro Villarino |
| Minister for Social Affairs and Gender Equality | María Consuelo Nguema Oyana |
| Minister for Public Service and Administrative Reform | Eucario Bakale Angue |
| Minister for Culture, Tourism and Artisanal Promotion | Rufino Ndong Esono Nchama |
| Minister of State at the Presidency of the Republic in charge of Diplomatic Missions | Alejandro Evuna Owono Asangono |
| Minister of State at the Presidency of the Government, in charge of regional integration | Baltasar Engonga Edjo |
| Minister of State for National Security | Nicolás Obama Nchama |
| Minister at the Presidency of the Republic, Head of Foreign Security | Juan Antonio Bibang Nchuchuma |
| Minister Secretary General of the Government Presidency | Baltasar Esono Eworo Nfono |
